NCSTN and APH1A

Data Source:
HPRD (in vivo, in vitro)

		NCSTN	APH1A
Description		nicastrin	aph-1 homolog A, gamma-secretase subunit
Image
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Azurophil Granule Membrane Sarcolemma Melanosome Extracellular Exosome Gamma-secretase Complex Integral Component Of Presynaptic Membrane	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	Endopeptidase Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding Growth Factor Receptor Binding	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Receptor Processing Learning Or Memory Positive Regulation Of Endopeptidase Activity Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neutrophil Degranulation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs			E-2012
Diseases		Acne inversa; Hidradenitis supprativa
GWAS		Post bronchodilator FEV1 in COPD ( 26634245)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26955885 26835600) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10	36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1
Entrez ID		23385	51107
HPRD ID		05584	06360
Ensembl ID		ENSG00000162736	ENSG00000117362
Uniprot IDs		B4DR82 Q92542	B4DUG7 Q96BI3
PDB IDs		2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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