APH1A and TRARG1

Data Source:
BioGRID (two hybrid)

		APH1A	TRARG1
Description		aph-1 homolog A, gamma-secretase subunit	trafficking regulator of GLUT4 (SLC2A4) 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane	Plasma Membrane Endomembrane System Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Cellular Response To Insulin Stimulus Glucose Import In Response To Insulin Stimulus Protein Localization To Plasma Membrane Endosome To Plasma Membrane Protein Transport
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		E-2012
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26955885 26835600) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1	101 interacting genes: APH1A APH1B AQP12B AQP2 ARL13B BCL2L13 BIK BSCL2 C6orf89 CCR4 CD300E CD53 CD79A CLDN12 CLDN7 CLDN8 CLEC10A CXCR1 CXCR2 DAGLA EBP EFNA4 ELOVL4 ERGIC3 FNDC9 FUT3 GJB3 GPR151 GPR42 GPR61 GPRC5D HSF2BP IFNGR2 IL3RA IRF1-AS1 KASH5 KCNC1 KRT34 KRTAP5-9 LAPTM4B LHFPL5 LY6E MEOX2 MFF MFSD14B MRM1 MRPS18B MTIF3 NPFFR2 NPY2R ODF4 OPN1LW OPRM1 OR7D4 OSTC PDZK1IP1 PLEKHB2 PSCA RHBDL1 RHCG RTP4 SCN3B SDCBP SGPL1 SLC10A1 SLC13A4 SLC14A2 SLC16A2 SLC1A5 SLC30A2 SLC34A2 SLC35F1 SLC36A1 SLC38A1 SLC38A11 SLC38A6 SLC39A1 SLC7A1 SLC7A14 SLCO3A1 SPAG4 SSMEM1 SYNPR TAAR9 TM4SF18 TMC4 TMEM179B TMEM237 TMEM248 TMEM31 TMEM45A TMEM52B TMEM69 TMEM71 TMEM80 TMEM9 TMPPE TTYH2 WFS1 YIPF6 ZDHHC4
Entrez ID		51107	286753
HPRD ID		06360	18248
Ensembl ID		ENSG00000117362	ENSG00000184811
Uniprot IDs		B4DUG7 Q96BI3	Q8IXB3
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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