KIF13B and MARK2

Data Source:
BioGRID (pull down, enzymatic study)

		KIF13B	MARK2
Description		kinesin family member 13B	microtubule affinity regulating kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Kinesin Complex Microtubule Microvillus Axon Paranode Region Of Axon	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Protein Kinase Binding 14-3-3 Protein Binding	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Targeting Microtubule-based Movement Signal Transduction T Cell Activation Regulation Of Axonogenesis	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels (X-11787) ( 23934736) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Response to statin therapy ( 20339536)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		3 interacting genes: DLG1 DLG4 MARK2	32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		23303	2011
HPRD ID		09556	02753
Ensembl ID		ENSG00000197892	ENSG00000072518
Uniprot IDs		Q9NQT8	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs		2COW 3FM8 3GBJ 3MDB	3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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