MARK2 and CAMK1

Data Source:
BioGRID (enzymatic study)

		MARK2	CAMK1
Description		microtubule affinity regulating kinase 2	calcium/calmodulin dependent protein kinase I
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation
Pathways			Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		2011	8536
HPRD ID		02753	05412
Ensembl ID		ENSG00000072518	ENSG00000134072
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	B0YIY3 Q14012
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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