PARD3 and LIMK2

Data Source:
HPRD (in vitro, in vivo)

		PARD3	LIMK2
Description		par-3 family cell polarity regulator	LIM domain kinase 2
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Apical Junction Complex Axonal Growth Cone	Nucleus Cytoplasm Cis-Golgi Network Centrosome Mitotic Spindle
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Spermatogenesis Phosphorylation Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs			Fostamatinib
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Fish- and plant-related diet ( 32066663) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663) Red cell distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		29 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN YWHAB YWHAG YWHAH YWHAZ	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		56288	3985
HPRD ID		05994	03585
Ensembl ID		ENSG00000148498	ENSG00000182541
Uniprot IDs		Q8TEW0	A0A024R1H6 A0A024R1M2 P53671
PDB IDs		2KOM	1X6A 4TPT 5NXD
Enriched GO Terms of Interacting Partners?
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