RHOBTB2 and PPM1D

Data Source:
BioGRID (two hybrid)

		RHOBTB2	PPM1D
Description		Rho related BTB domain containing 2	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Regulation Of Small GTPase Mediated Signal Transduction	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways		RHOBTB2 GTPase cycle	Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		23221	8493
HPRD ID		06300	05482
Ensembl ID		ENSG00000008853	ENSG00000170836
Uniprot IDs		Q9BYZ6	A0A0S2Z4M2 O15297
PDB IDs
Enriched GO Terms of Interacting Partners?
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