WDFY3 and CEP76

Data Source:
BioGRID (two hybrid)

		WDFY3	CEP76
Description		WD repeat and FYVE domain containing 3	centrosomal protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Autophagosome Cytosol Plasma Membrane Inclusion Body PML Body Extrinsic Component Of Membrane Axon Nuclear Membrane Atg12-Atg5-Atg16 Complex Perikaryon Extrinsic Component Of Autophagosome Membrane	Centrosome Centriole Cytosol Protein-containing Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Metal Ion Binding	Protein Binding
	Biological Process	Multicellular Organism Development Aggrephagy	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Monocyte percentage of white cells ( 32888494) Oropharynx cancer ( 27749845)
Interacting Genes		15 interacting genes: ATG5 CEP76 GABARAPL1 GABARAPL2 GRB2 MAP1LC3C MDFI PRMT1 PRMT6 RABGAP1L STAT3 SUV39H1 TNS2 TRIM39 ZBTB44	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIR1 COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HSF2 HSPB7 ILVBL IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		23001	79959
HPRD ID		10304	12694
Ensembl ID		ENSG00000163625	ENSG00000101624
Uniprot IDs		A0A024RDC2 Q8IZQ1	B4DP81 Q8TAP6
PDB IDs		3WIM
Enriched GO Terms of Interacting Partners?
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