RPIA and PCDH7

Data Source:
BioGRID (affinity chromatography technology)

		RPIA	PCDH7
Description		ribose 5-phosphate isomerase A	protocadherin 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Platelet Alpha Granule Membrane
	Molecular Function	Ribose-5-phosphate Isomerase Activity Protein Binding Identical Protein Binding Monosaccharide Binding	Calcium Ion Binding
	Biological Process	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Ribose Phosphate Metabolic Process	Platelet Degranulation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Pathways		RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway	Platelet degranulation
Drugs		4-phospho-L-threonic acid
Diseases
GWAS		Blood protein levels ( 30072576)	Adult body size ( 32376654) Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 30820047) Attention deficit hyperactivity disorder ( 32279069) Body size at age 10 ( 32376654) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) Electroencephalogram traits ( 25387704) Epilepsy ( 25087078) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Hip circumference adjusted for BMI ( 28552196) Influenza A (H1N1) infection ( 26379185) Lipid traits ( 22028671) Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Menarche (age at onset) ( 25231870) Mild influenza (H1N1) infection ( 26379185) Mouth morphology (principal component model) ( 30174134) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive astigmatism ( 25367360) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to ziprazidone in schizophrenia ( 29503163) Smoking status (ever vs never smokers) ( 30643258) Underweight status ( 25133637) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		19 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1	2 interacting genes: MTDH PPP1CA
Entrez ID		22934	5099
HPRD ID		01589	04288
Ensembl ID		ENSG00000153574	ENSG00000169851
Uniprot IDs		P49247	O60245
PDB IDs			2YST
Enriched GO Terms of Interacting Partners?
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