RAB18 and TOM1L1

Data Source:
HPRD (two hybrid)

		RAB18	TOM1L1
Description		RAB18, member RAS oncogene family	target of myb1 like 1 membrane trafficking protein
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Apical Plasma Membrane Secretory Granule Membrane Endoplasmic Reticulum Tubular Network	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Viral Process Lipid Droplet Organization Neutrophil Degranulation Endoplasmic Reticulum Tubular Network Organization	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278)	Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		10 interacting genes: AQP6 CHM ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1	29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP
Entrez ID		22931	10040
HPRD ID		03731	05266
Ensembl ID		ENSG00000099246	ENSG00000141198
Uniprot IDs		A0A087X163 B7Z4P9 B7Z5V3 Q9NP72	O75674 Q8NI65
PDB IDs		1X3S	3RRU
Enriched GO Terms of Interacting Partners?
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