MAPRE3 and APC2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAPRE3	APC2
Description		microtubule associated protein RP/EB family member 3	APC regulator of WNT signaling pathway 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End	Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Midbody Beta-catenin Destruction Complex Lamellipodium Membrane Filamentous Actin Intercellular Bridge Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Protein Binding Beta-catenin Binding Microtubule Binding Gamma-catenin Binding
	Biological Process	Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Spindle Assembly Cell Division Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end	Microtubule Cytoskeleton Organization Cell Fate Specification Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Nervous System Development Wnt Signaling Pathway Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity
Pathways
Drugs
Diseases			Colorectal cancer
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Lean body mass ( 28552196)
Interacting Genes		60 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 C4orf45 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GAS2L2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE1 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B TAOK2 TEX43 TLE5 TRAIP TRIM14 TROAP TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547	4 interacting genes: AXIN2 CTNNB1 MAPRE1 MAPRE3
Entrez ID		22924	10297
HPRD ID		16156	09802
Ensembl ID		ENSG00000084764	ENSG00000115266
Uniprot IDs		Q9UPY8	O95996
PDB IDs		1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7
Enriched GO Terms of Interacting Partners?
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