MAPRE1 and MAPRE2

Data Source:
BioGRID (two hybrid)

		MAPRE1	MAPRE2
Description		microtubule associated protein RP/EB family member 1	microtubule associated protein RP/EB family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Spindle Midzone Mitotic Spindle Astral Microtubule End	Cytoplasm Microtubule Organizing Center Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Bundle Formation Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Positive Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end Non-motile Cilium Assembly	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly Protein Localization To Microtubule Plus-end
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)
Interacting Genes		55 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GAS2L2 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MAPRE2 MAPRE3 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB ZNF653	28 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 CRTAC1 DDIT4L FBXO7 GAS2L2 GTSE1 LMNA LMO2 LNX1 MAPRE1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC
Entrez ID		22919	10982
HPRD ID		04379	16157
Ensembl ID		ENSG00000101367	ENSG00000166974
Uniprot IDs		Q15691	A0A024RC33 Q15555
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?
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