MAPRE2 and CLASP2

Data Source:
HPRD (in vitro, in vivo)

		MAPRE2	CLASP2
Description		microtubule associated protein RP/EB family member 2	cytoplasmic linker associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone	Kinetochore Condensed Chromosome Kinetochore Cytoplasm Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Kinetochore Microtubule Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cell Leading Edge Ruffle Membrane Basal Cortex Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding
	Biological Process	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly Protein Localization To Microtubule Plus-end	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)	Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 CRTAC1 DDIT4L FBXO7 GAS2L2 GTSE1 LMNA LMO2 LNX1 MAPRE1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC	15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 MARK3 PYGM RBFOX2 SRPK2
Entrez ID		10982	23122
HPRD ID		16157	12054
Ensembl ID		ENSG00000166974	ENSG00000163539
Uniprot IDs		A0A024RC33 Q15555	E3W994 E7ERI8 O75122
PDB IDs			3WOY 5NR4
Enriched GO Terms of Interacting Partners?
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