ZNF365 and NDE1

Data Source:
HPRD (two hybrid, in vivo)

		ZNF365	NDE1
Description		zinc finger protein 365	nudE neurodevelopment protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriolar Satellite Intracellular Membrane-bounded Organelle	Kinetochore Condensed Chromosome Kinetochore Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding Identical Protein Binding
	Biological Process	Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Neuron Projection Development Cerebellar Molecular Layer Morphogenesis Positive Regulation Of Oligodendrocyte Differentiation Dendritic Spine Morphogenesis Regulation Of DNA Strand Resection Involved In Replication Fork Processing Dendrite Arborization	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Cerebral Cortex Development Cell Differentiation Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 23042114 26482879) Autism spectrum disorder-related traits ( 25534755) Basal cell carcinoma ( 31174203 28177523) Bitter non-alcoholic beverage consumption ( 31046077) Breast cancer ( 21908515 29059683 23535729 23535733 27117709 20453838) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 18587394 30500874 25489960 28067908 22936669 22412388 21102463 32581322) Diastolic blood pressure ( 27841878) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Ewing sarcoma ( 22327514) Hypothyroidism ( 27182965) Inflammatory bowel disease ( 28067908) Intelligence ( 22449649) Keratinocyte cancer (MTAG) ( 31174203) Mammographic density (dense area) ( 25342443) Mammographic density (non-dense area) ( 25342443) Multiple sclerosis ( 31604244) Narcolepsy ( 24204295 23459209) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Percent mammographic density ( 21278746 25342443) Psoriasis ( 28537254) Schizophrenia ( 30285260) Sudden cardiac arrest in coronary artery disease ( 23593153) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424 28714469) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Vogt-Koyanagi-Harada syndrome ( 25108386) White blood cell count ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Mean platelet volume ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		3 interacting genes: APP DISC1 NDE1	27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398
Entrez ID		22891	54820
HPRD ID		06380	14815
Ensembl ID		ENSG00000138311	ENSG00000072864
Uniprot IDs		Q70YC4 Q70YC5	Q9NXR1 X5DP35 X5DR54
PDB IDs
Enriched GO Terms of Interacting Partners?
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