NDE1 and ZNF398

Data Source:
BioGRID (two hybrid)

		NDE1	ZNF398
Description		nudE neurodevelopment protein 1	zinc finger protein 398
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow	Nucleus
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Cerebral Cortex Development Cell Differentiation Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Mean platelet volume ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398	22 interacting genes: - AQP1 C1orf109 CABP5 CHD2 CIB3 CLK2 DGCR6 ELMO1 EMD ESR1 GPATCH2L MAGOHB MFAP1 NCDN NDE1 NUDT22 OPTN PLEKHF2 SMARCB1 TRIM41 ZNF783
Entrez ID		54820	57541
HPRD ID		14815	18336
Ensembl ID		ENSG00000072864	ENSG00000197024
Uniprot IDs		Q9NXR1 X5DP35 X5DR54	A0A090N7S8 A0A090N8F2 B4DXA9 Q8TD17
PDB IDs
Enriched GO Terms of Interacting Partners?
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