MON1B and VPS18

Data Source:
BioGRID (two hybrid, pull down)

		MON1B	VPS18
Description		MON1 homolog B, secretory trafficking associated	VPS18 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mon1-Ccz1 Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Vacuole Vesicle-mediated Transport Early Viral Transcription Late Viral Transcription	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Immune response to measles-mumps-rubella vaccine ( 24811271) Metabolite levels ( 23823483) Multisite chronic pain ( 31194737) Number of sexual partners ( 30643258)	Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		6 interacting genes: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41	20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45
Entrez ID		22879	57617
HPRD ID		12342	09776
Ensembl ID		ENSG00000103111	ENSG00000104142
Uniprot IDs		B4DKA0 E7EW32 Q6ZR87 Q7L1V2	A0A024R9R3 Q9P253
PDB IDs
Enriched GO Terms of Interacting Partners?
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