VPS18 and VPS45

Data Source:
HPRD (in vivo)

		VPS18	VPS45
Description		VPS18 core subunit of CORVET and HOPS complexes	vacuolar protein sorting 45 homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Golgi Membrane Cellular_component Golgi Apparatus Endosome Membrane Integral Component Of Membrane
	Molecular Function	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Molecular_function Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Blood Coagulation Vesicle-mediated Transport
Pathways			Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Interacting Genes		20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	11 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNTG1 STX16 VPS11 VPS18
Entrez ID		57617	11311
HPRD ID		09776	10301
Ensembl ID		ENSG00000104142	ENSG00000136631
Uniprot IDs		A0A024R9R3 Q9P253	A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?