NLGN1 and DLG2

Data Source:
BioGRID (two hybrid)

		NLGN1	DLG2
Description		neuroligin 1	discs large MAGUK scaffold protein 2
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Dendrite Filopodium Tip Synaptic Cleft Dendritic Spine Dendritic Shaft Receptor Complex Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Postsynapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Guanylate Kinase Activity Protein Binding Kinase Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Chemical Synaptic Transmission Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Postsynaptic Specialization Assembly Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Presynapse Assembly Synaptic Membrane Adhesion Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Localization To Synapse Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	MAPK Cascade Chemical Synaptic Transmission Embryo Development Negative Regulation Of Phosphatase Activity Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Regulation Of NMDA Receptor Activity
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32154731) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)	Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)
Interacting Genes		6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	52 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A
Entrez ID		22871	1740
HPRD ID		07195	04663
Ensembl ID		ENSG00000169760	ENSG00000150672
Uniprot IDs		Q8N2Q7	B7Z2T4 Q15700
PDB IDs		5OJ6 5OJK	2BYG 2HE2
Enriched GO Terms of Interacting Partners?
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