XRN2 and STK39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		XRN2	STK39
Description		5'-3' exoribonuclease 2	serine/threonine kinase 39
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4
Entrez ID		22803	27347
HPRD ID		10309	09627
Ensembl ID		ENSG00000088930	ENSG00000198648
Uniprot IDs		B4DZC3 Q9H0D6	Q9UEW8
PDB IDs
Enriched GO Terms of Interacting Partners?
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