FHIT and RAB40B

Data Source:
BioGRID (two hybrid)

		FHIT	RAB40B
Description		fragile histidine triad diadenosine triphosphatase	RAB40B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane	Nuclear Envelope Endosome Plasma Membrane Synaptic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity	GTPase Activity Protein Binding GTP Binding
	Biological Process	Purine Nucleotide Metabolic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Protein Ubiquitination Intracellular Signal Transduction Protein Localization To Plasma Membrane Toxin Transport
Pathways			RAB geranylgeranylation
Drugs		Adenosine monotungstate Ado-P-Ch2-P-Ps-Ado
Diseases		Non-small cell lung cancer Small cell lung cancer
GWAS		Adult body size ( 32376654) Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Broad depression or schizophrenia ( 30626913) Bronchopulmonary dysplasia ( 23897914) Caudal anterior-cingulate cortex volume ( 31530798) Cognitive function ( 25644384) Conotruncal heart defects ( 24800985) Depressive symptom measurement or major depressive disorder ( 28049566) Differentiated thyroid cancer ( 28703219) Falling risk ( 32999390) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Intracranial aneurysm ( 29531279) Iris color (L* coordinate) ( 30895295) Irritable bowel syndrome ( 29673008) Lung function (maximal voluntary ventilation) ( 29095316) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643) Major depressive disorder ( 20125088) Methadone dose in opioid dependence ( 28115739) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Papillary thyroid cancer ( 28703219) Pars triangularis volume ( 31530798) Photic sneeze reflex ( 27182965) Postoperative myocardial infarction after cardiac surgery ( 30678657) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553) Schizophrenia ( 30285260) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference ( 28552196) Weight ( 28552196)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		10 interacting genes: CTNNB1 DDIT4L FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I	6 interacting genes: ANKRD27 APP EFEMP2 FHIT FHL3 WFDC1
Entrez ID		2272	10966
HPRD ID		03096	11472
Ensembl ID		ENSG00000189283	ENSG00000141542
Uniprot IDs		A0A024R366 P49789	Q12829
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?
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