FGFR1 and PLCG1

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		FGFR1	PLCG1
Description		fibroblast growth factor receptor 1	phospholipase C gamma 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Receptor-receptor Interaction	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding Calcium-dependent Phospholipase C Activity
	Biological Process	MAPK Cascade Skeletal System Development Neuron Migration Epithelial To Mesenchymal Transition Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Skeletal System Morphogenesis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Phospholipase C Activity Viral Process Cell Migration Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Signaling by activated point mutants of FGFR1 Signaling by FGFR1 in disease Signaling by plasma membrane FGFR1 fusions	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
Drugs		Palifermin Sorafenib Heparin 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone XL999 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Regorafenib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib Pralsetinib
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) Osteoglophonic dysplasia (OD); Osteoglophonic dwarfism (OGD) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Adult body size ( 32376654) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Birth weight ( 31043758) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Nonsyndromic cleft lip with cleft palate ( 28232668) PR interval ( 30046033 32439900) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Schizophrenia ( 29483656) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		67 interacting genes: BNIP2 CDH1 CREBBP CRK CTPS2 EPHA4 ERBB2 ERBB3 FBXO7 FDPS FGF1 FGF10 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 HTR1A HULC IL17RD ITGB3 ITK KLB KPNB1 L1CAM LDHA MFHAS1 MMP2 NCAM1 NCK1 NCK2 NECTIN1 NEDD4 NRP1 PDGFRB PDK1 PDP1 PIK3R1 PIK3R2 PKM PLCG1 PTK6 PTPN1 RARA RASA1 RPS6KA1 RPS6KA3 RTN1 RTN3 SH3BP2 SHC1 SLA SOS1 TNK2 TNS2 VAV1 YES1	111 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		2260	5335
HPRD ID		00634	01398
Ensembl ID		ENSG00000077782	ENSG00000124181
Uniprot IDs		A0A0S2Z3Q6 A0A3B3ISD1 P11362	P19174 Q4LE43 Q9UFY1
PDB IDs		1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWB 4UWC 4UWY 4V01 4V04 4V05 4WUN 4ZSA 5A46 5A4C 5AM6 5AM7 5B7V 5EW8 5FLF 5O49 5O4A 5UQ0 5UR1 5VND 5W21 5W59 5Z0S 5ZV2 6C18 6C19 6C1B 6C1C 6C1O 6ITJ 6MZQ 6MZW 6NVL 6P68 6P69	1HSQ 2HSP 4EY0 4FBN
Enriched GO Terms of Interacting Partners?
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