PLCG1 and EPHB2

Data Source:
BioGRID (two hybrid)

		PLCG1	EPHB2
Description		phospholipase C gamma 1	EPH receptor B2
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Postsynapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding Calcium-dependent Phospholipase C Activity	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Phospholipase C Activity Viral Process Cell Migration Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Urogenital System Development Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Or Memory Learning Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Inactivation Of MAPKK Activity Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Projection Retraction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways		ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants	EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		111 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	39 interacting genes: ABL1 ABL2 ACP1 AFDN AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERBB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1
Entrez ID		5335	2048
HPRD ID		01398	02997
Ensembl ID		ENSG00000124181	ENSG00000133216
Uniprot IDs		P19174 Q4LE43 Q9UFY1	B4DSE0 P29323 Q4LE53 Q6NVW1
PDB IDs		1HSQ 2HSP 4EY0 4FBN	1B4F 1F0M 2QBX 3ZFM
Enriched GO Terms of Interacting Partners?
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