FDX1 and RDH5

Data Source:
BioGRID (affinity chromatography technology)

		FDX1	RDH5
Description		ferredoxin 1	retinol dehydrogenase 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Membrane Cell Body
	Molecular Function	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding	Retinol Dehydrogenase Activity Protein Homodimerization Activity Androsterone Dehydrogenase Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin	Retinoid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process Response To Stimulus
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway
Drugs		Mitotane	NADH Vitamin A
Diseases			Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254)	Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	3 interacting genes: ORC4 RGR RLBP1
Entrez ID		2230	5959
HPRD ID		00059	03370
Ensembl ID		ENSG00000137714	ENSG00000135437
Uniprot IDs		P10109	A0A024RB18 Q92781
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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