FDX1 and CYP11B2

Data Source:
HPRD (in vitro)

		FDX1	CYP11B2
Description		ferredoxin 1	cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Drugs		Mitotane	Spironolactone Osilodrostat
Diseases			Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254)	Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		2230	1585
HPRD ID		00059	00492
Ensembl ID		ENSG00000137714	ENSG00000179142
Uniprot IDs		P10109	P19099
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M	4DVQ 4FDH 4ZGX 6XZ8 6XZ9
Enriched GO Terms of Interacting Partners?
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