FCGR2B and AP3B1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)
HPRD (in vivo)

		FCGR2B	AP3B1
Description		Fc fragment of IgG receptor IIb	adaptor related protein complex 3 subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Dendritic Spine Cell Body	Mitochondrion Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Synapse Axon Cytoplasm
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Protein Binding Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Regulation Of Signaling Receptor Activity Viral Process Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Neuron Death Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Cellular Protein Modification Process Protein Targeting To Lysosome Cellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Regulation Of Catalytic Activity Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF fusions
Drugs		Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases		Systemic lupus erythematosus	Hermansky-Pudlak syndrome (HPS)
GWAS		Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488 28240269) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) IgG levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Lipid metabolism phenotypes ( 22286219) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Rheumatoid arthritis ( 30423114) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Insulin resistance/response ( 21901158) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)
Interacting Genes		15 interacting genes: APCS BLK CRP ERG28 GAB1 GRB2 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PRKCA PTPN11 PTPN6	14 interacting genes: AP3D1 AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3
Entrez ID		2213	8546
HPRD ID		06849	04551
Ensembl ID		ENSG00000072694	ENSG00000132842
Uniprot IDs		P31994	A0A0S2Z5J4 O00203
PDB IDs		2FCB 3WJJ 5OCC
Enriched GO Terms of Interacting Partners?
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