FAM124A and PRKG1

Data Source:
BioGRID (two hybrid)

		FAM124A	PRKG1
Description		family with sequence similarity 124 member A	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process		Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Ca2+ pathway
Drugs
Diseases
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Lipoprotein (a) levels ( 30108283) Metabolite levels ( 23823483) Placental abruption ( 29884306) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-negative) ( 24532677)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		30 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 IL16 INO80E KIFC3 LNX1 NCK2 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	39 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP WDR77 ZNF646
Entrez ID		220108	5592
HPRD ID		08704	08910
Ensembl ID		ENSG00000150510	ENSG00000185532
Uniprot IDs		Q86V42	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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