PRKG1 and TRPC3

Data Source:
HPRD (in vitro)

		PRKG1	TRPC3
Description		protein kinase cGMP-dependent 1	transient receptor potential cation channel subfamily C member 3
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Ca2+ pathway	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)	Asthma ( 31959851) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		39 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP WDR77 ZNF646	20 interacting genes: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		5592	7222
HPRD ID		08910	15999
Ensembl ID		ENSG00000185532	ENSG00000138741
Uniprot IDs		Q13976	Q13507
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T	5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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