TYSND1 and ACOX1

Data Source:
BioGRID (enzymatic study)

		TYSND1	ACOX1
Description		trypsin like peroxisomal matrix peptidase 1	acyl-CoA oxidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol Membrane	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity	Acyl-CoA Oxidase Activity Fatty Acid Binding Palmitoyl-CoA Oxidase Activity PDZ Domain Binding Protein Homodimerization Activity Protein N-terminus Binding Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Proteolysis Protein Targeting To Peroxisome Protein Processing Regulation Of Fatty Acid Beta-oxidation	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Protein Targeting To Peroxisome Lipid Metabolic Process Prostaglandin Metabolic Process Spermatogenesis Fatty Acid Catabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Homeostasis
Pathways		Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins TYSND1 cleaves peroxisomal proteins	Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs			Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS			Body mass index ( 28552196) Diastolic blood pressure ( 27841878) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878) Urinary metabolite levels in chronic kidney disease ( 31959995) White matter hyperintensity burden ( 25663218)
Interacting Genes		2 interacting genes: ACOX1 TH	3 interacting genes: SCP2 SLC2A4 TYSND1
Entrez ID		219743	51
HPRD ID		15593	02030
Ensembl ID		ENSG00000156521	ENSG00000161533
Uniprot IDs		Q2T9J0	Q15067
PDB IDs
Enriched GO Terms of Interacting Partners?
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