ETV4 and SAE1

Data Source:
BioGRID (enzymatic study)

		ETV4	SAE1
Description		ETS variant transcription factor 4	SUMO1 activating enzyme subunit 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Ubiquitination Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		MAPK6/MAPK4 signaling	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases		Ewing's sarcoma Prostate cancer
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN MEOX2 SAE1 SMAD4 SRF STK11 UBA2	22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		2118	10055
HPRD ID		02833	18010
Ensembl ID		ENSG00000175832	ENSG00000142230
Uniprot IDs		P43268	A0A024R0R4 Q9UBE0
PDB IDs		4CO8 4UUV 5ILU	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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