ETV4 and UBA2

Data Source:
BioGRID (enzymatic study)

		ETV4	UBA2
Description		ETS variant transcription factor 4	ubiquitin like modifier activating enzyme 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus	Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation
Pathways		MAPK6/MAPK4 signaling	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases		Ewing's sarcoma Prostate cancer
GWAS
Interacting Genes		14 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN MEOX2 SAE1 SMAD4 SRF STK11 UBA2	17 interacting genes: BRIX1 CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I
Entrez ID		2118	10054
HPRD ID		02833	11658
Ensembl ID		ENSG00000175832	ENSG00000126261
Uniprot IDs		P43268	Q9UBT2
PDB IDs		4CO8 4UUV 5ILU	1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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