AKT2 and PIP5K1C

Data Source:
BioGRID (enzymatic study)

		AKT2	PIP5K1C
Description		AKT serine/threonine kinase 2	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Early Endosome Cytosol Plasma Membrane Cell Cortex Ruffle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Mammary Gland Epithelial Cell Differentiation Intracellular Protein Transmembrane Transport Regulation Of Cell Cycle Arrest Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Activation Of GTPase Activity Retinal Rod Cell Apoptotic Process Positive Regulation Of Cell Motility	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases		Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Ovarian cancer	Lethal congenital contractural syndrome (LCCS)
GWAS		Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		44 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SNX27 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	17 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SRC TLN2
Entrez ID		208	23396
HPRD ID		01262	05834
Ensembl ID		ENSG00000105221	ENSG00000186111
Uniprot IDs		B4DG79 P31751	O60331
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?
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