PIP5K1C and LAPTM4B

Data Source:
BioGRID (pull down)

		PIP5K1C	LAPTM4B
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	lysosomal protein transmembrane 4 beta
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization
Pathways		Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis
Drugs
Diseases		Lethal congenital contractural syndrome (LCCS)
GWAS			Metabolite levels ( 23823483) QT interval ( 24952745)
Interacting Genes		17 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SRC TLN2	21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1
Entrez ID		23396	55353
HPRD ID		05834	13960
Ensembl ID		ENSG00000186111	ENSG00000104341
Uniprot IDs		O60331	Q86VI4
PDB IDs		2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?
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