PPP2CA and HTT

Data Source:
BioGRID (unspecified method)

		PPP2CA	HTT
Description		protein phosphatase 2 catalytic subunit alpha	huntingtin
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	P53 Binding Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of Protein Phosphorylation Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Response To Organic Substance Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Peptidyl-threonine Dephosphorylation Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Peptidyl-serine Dephosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Microtubule Binding Positive Regulation Of Microtubule Binding	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Golgi Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Microtubule-based Transport Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of MECP2 expression and activity
Drugs		Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Copper
Diseases			Huntington's disease (HD)
GWAS			Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		96 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 VAC14 VDR XRN1 YPEL3	110 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		5515	3064
HPRD ID		08912	00883
Ensembl ID		ENSG00000113575	ENSG00000197386
Uniprot IDs		B3KUN1 P67775	P42858
PDB IDs		2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 5W0W 6NTS	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O
Enriched GO Terms of Interacting Partners?
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