EPRS1 and DUS2

Data Source:
HPRD (in vivo)

		EPRS1	DUS2
Description		glutamyl-prolyl-tRNA synthetase 1	dihydrouridine synthase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex	Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell	TRNA Dihydrouridine Synthesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol	tRNA modification in the nucleus and cytosol
Drugs		Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS			Eosinophil counts ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)
Interacting Genes		89 interacting genes: AIMP2 ARL4D CDC42 DUS2 DUX4 EEF1D ESR1 HSP90AA1 IARS1 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NELFCD PTEN RARS1 SUMO2 SYNCRIP TAB1	4 interacting genes: EPRS1 NECTIN2 SMN1 TK1
Entrez ID		2058	54920
HPRD ID		00703	08624
Ensembl ID		ENSG00000136628	ENSG00000167264
Uniprot IDs		P07814	A0A024R6Z7 B4DKP8 E7EUN9 Q9NX74
PDB IDs		1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6	4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00
Enriched GO Terms of Interacting Partners?
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