EPRS1 and MIR214

Data Source:
BioGRID (unspecified method)

		EPRS1	MIR214
Description		glutamyl-prolyl-tRNA synthetase 1	microRNA 214
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex	Nucleus Perinuclear Region Of Cytoplasm Extracellular Vesicle
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Gene Silencing By MiRNA Negative Regulation Of Necroptotic Process Cellular Response To Hypoxia Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Connective Tissue Replacement
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol
Drugs		Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS			Height ( 31562340)
Interacting Genes		89 interacting genes: AIMP2 ARL4D CDC42 DUS2 DUX4 EEF1D ESR1 HSP90AA1 IARS1 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NELFCD PTEN RARS1 SUMO2 SYNCRIP TAB1	92 interacting genes: AIMP1 AIMP2 AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PTBP1 PTCD3 PUF60 PUM1 PUM2 QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZFR ZNF346
Entrez ID		2058	406996
HPRD ID		00703
Ensembl ID		ENSG00000136628	ENSG00000283844
Uniprot IDs		P07814
PDB IDs		1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6
Enriched GO Terms of Interacting Partners?
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