EPHA4 and NGEF

Data Source:
HPRD (in vivo, two hybrid)

		EPHA4	NGEF
Description		EPH receptor A4	neuronal guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Neuron Projection Dendritic Spine Dendritic Shaft Perikaryon Receptor Complex Axon Terminus Axonal Growth Cone Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytosol Membrane Growth Cone
	Molecular Function	Amyloid-beta Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Positive Regulation Of Kinase Activity Adherens Junction Organization Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity	G Protein-coupled Receptor Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		17 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC TNS3	14 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63
Entrez ID		2043	25791
HPRD ID		03719	10442
Ensembl ID		ENSG00000116106	ENSG00000066248
Uniprot IDs		A1MA61 P54764	B4DDI2 Q8N5V2
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2
Enriched GO Terms of Interacting Partners?
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