CAMK1 and GCM1

Data Source:
BioGRID (enzymatic study)

		CAMK1	GCM1
Description		calcium/calmodulin dependent protein kinase I	glial cells missing transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Gliogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Fate Commitment Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Branching Involved In Labyrinthine Layer Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib
Diseases
GWAS			Cerebrospinal fluid AB1-42 levels ( 26252872)
Interacting Genes		22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1	9 interacting genes: CAMK1 CREBBP DUSP23 HDAC1 HDAC3 HDAC4 HDAC5 SENP1 UBE2I
Entrez ID		8536	8521
HPRD ID		05412	04757
Ensembl ID		ENSG00000134072	ENSG00000137270
Uniprot IDs		B0YIY3 Q14012	Q9NP62
PDB IDs		4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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