ELN and FKBP10

Data Source:
HPRD (in vitro, in vivo)

		ELN	FKBP10
Description		elastin	FKBP prolyl isomerase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Elastic Fiber	Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Calcium Ion Binding Protein Binding FK506 Binding
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation	Protein Peptidyl-prolyl Isomerization In Utero Embryonic Development Peptidyl-lysine Hydroxylation Peptidyl-proline Modification Collagen Fibril Organization Aorta Morphogenesis Wound Healing Extracellular Matrix Assembly
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Rofecoxib
Diseases		Congenital supravalvar aortic stenosis Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome	Bruck syndrome
GWAS		Diverticular disease ( 30177863) Height ( 31562340)	Eosinophil counts ( 32888494)
Interacting Genes		22 interacting genes: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PRTN3 SPINK1	3 interacting genes: CDC42 ELN SLC2A4
Entrez ID		2006	60681
HPRD ID		00556	09522
Ensembl ID		ENSG00000049540	ENSG00000141756
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	A0A024R1W3 Q658U4 Q8NAG5 Q96AY3
PDB IDs
Enriched GO Terms of Interacting Partners?
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