ELN and FCN1

Data Source:
HPRD (in vitro)

		ELN	FCN1
Description		elastin	ficolin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Elastic Fiber	Extracellular Region Collagen Trimer Extracellular Space Extrinsic Component Of External Side Of Plasma Membrane Secretory Granule Lumen Collagen-containing Extracellular Matrix Ficolin-1-rich Granule Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	G Protein-coupled Receptor Binding Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding Carbohydrate Derivative Binding
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation	Complement Activation, Lectin Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Complement Activation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Protein Localization To Cell Surface Neutrophil Degranulation Recognition Of Apoptotic Cell Negative Regulation Of Viral Entry Into Host Cell
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation
Drugs		Rofecoxib
Diseases		Congenital supravalvar aortic stenosis Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Diverticular disease ( 30177863) Height ( 31562340)	Blood protein levels ( 30072576 29875488 28240269) Trans-epidermal water loss ( 28011148)
Interacting Genes		22 interacting genes: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PRTN3 SPINK1	2 interacting genes: ELN TGFB1
Entrez ID		2006	2219
HPRD ID		00556	03153
Ensembl ID		ENSG00000049540	ENSG00000085265
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	O00602
PDB IDs			2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?
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