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ELN and FCN1
Data Source:
HPRD
(in vitro)
ELN
FCN1
Description
elastin
ficolin 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Collagen-containing Extracellular Matrix
Elastic Fiber
Extracellular Region
Collagen Trimer
Extracellular Space
Extrinsic Component Of External Side Of Plasma Membrane
Secretory Granule Lumen
Collagen-containing Extracellular Matrix
Ficolin-1-rich Granule Lumen
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Constituent Conferring Elasticity
Extracellular Matrix Binding
G Protein-coupled Receptor Binding
Antigen Binding
Signaling Receptor Binding
Protein Binding
Carbohydrate Binding
Sialic Acid Binding
Pattern Recognition Receptor Activity
Metal Ion Binding
Carbohydrate Derivative Binding
Biological Process
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Skeletal Muscle Tissue Development
Respiratory Gaseous Exchange By Respiratory System
Blood Circulation
Animal Organ Morphogenesis
Extracellular Matrix Organization
Regulation Of Actin Filament Polymerization
Stress Fiber Assembly
Regulation Of Smooth Muscle Cell Proliferation
Complement Activation, Lectin Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Complement Activation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Interleukin-8 Production
Protein Localization To Cell Surface
Neutrophil Degranulation
Recognition Of Apoptotic Cell
Negative Regulation Of Viral Entry Into Host Cell
Pathways
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Neutrophil degranulation
Drugs
Rofecoxib
Diseases
Congenital supravalvar aortic stenosis
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Diverticular disease (
30177863
)
Height (
31562340
)
Blood protein levels (
30072576
29875488
28240269
)
Trans-epidermal water loss (
28011148
)
Interacting Genes
22 interacting genes:
ASS1
BGN
CKMT2
CLU
DCN
ELANE
FBLN1
FBLN2
FBN1
FBN2
FCN1
FKBP10
LGALS3
LOX
LOXL1
LYZ
MAGEH1
MFAP2
MTDH
NID2
PRTN3
SPINK1
2 interacting genes:
ELN
TGFB1
Entrez ID
2006
2219
HPRD ID
00556
03153
Ensembl ID
ENSG00000049540
ENSG00000085265
Uniprot IDs
B3KRT8
B4E3S4
E7EN65
E7ENM0
G3V0G6
G5E950
P15502
Q59H17
Q6ZUN2
Q8NBI4
O00602
PDB IDs
2D39
2JHH
2JHI
2JHK
2JHL
2JHM
2WNP
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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