FOXD4L1 and EXOSC8

Data Source:
BioGRID (two hybrid)

		FOXD4L1	EXOSC8
Description		forkhead box D4 like 1	exosome component 8
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Cell Differentiation	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Depressive symptom (sleep problems) (binary trait) ( 31530331)
Interacting Genes		23 interacting genes: ABI2 BAG3 BOLL CARD9 CCDC57 CYSRT1 EXOSC8 GPRASP2 HGS HMG20A HNRNPK KRT34 KRTAP12-2 KRTAP6-2 KRTAP6-3 MAPRE3 MDFI PNMA1 PRDM6 PSME3 RBPMS2 TRIP6 WWOX	74 interacting genes: AEN ATF2 C22orf39 CCDC28A-AS1 CNNM3 COL23A1 COX5A CRMP1 CWC22 DDIT4L DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 GEM HAPLN2 HOXB9 INCA1 KANK2 KCNJ11 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MKRN1 MORN4 MPHOSPH6 MTREX MYOZ1 NEDD9 NTAQ1 OTUD4 PALS2 PHF21A PIAS2 POLDIP3 RASD1 RASSF1 REL RFC5 RPP14 RUSC1 RXRB SLAIN1 SNAI1 SNRPB SNRPC SOCS7 SPATC1L TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP2 USP6 XRN1 XRN2 ZFP36
Entrez ID		200350	11340
HPRD ID		17010	09351
Ensembl ID		ENSG00000184492	ENSG00000120699
Uniprot IDs		B3KVK3 Q9NU39	Q96B26
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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