EXOSC8 and EXOSC4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		EXOSC8	EXOSC4
Description		exosome component 8	exosome component 4
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle
	Molecular Function	Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		74 interacting genes: AEN ATF2 C22orf39 CCDC28A-AS1 CNNM3 COL23A1 COX5A CRMP1 CWC22 DDIT4L DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 GEM HAPLN2 HOXB9 INCA1 KANK2 KCNJ11 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MKRN1 MORN4 MPHOSPH6 MTREX MYOZ1 NEDD9 NTAQ1 OTUD4 PALS2 PHF21A PIAS2 POLDIP3 RASD1 RASSF1 REL RFC5 RPP14 RUSC1 RXRB SLAIN1 SNAI1 SNRPB SNRPC SOCS7 SPATC1L TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP2 USP6 XRN1 XRN2 ZFP36	33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		11340	54512
HPRD ID		09351	16221
Ensembl ID		ENSG00000120699	ENSG00000178896
Uniprot IDs		Q96B26	Q9NPD3
PDB IDs		2NN6 6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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