LCE4A and VWC2

Data Source:
BioGRID (two hybrid)

		LCE4A	VWC2
Description		late cornified envelope 4A	von Willebrand factor C domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Basement Membrane Interstitial Matrix Extracellular Space AMPA Glutamate Receptor Complex Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Molecular_function Protein Binding
	Biological Process	Keratinization	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		69 interacting genes: ADAMTSL4 CRCT1 CREB5 CYSRT1 FUCA2 GRN HOXA1 HSD3B7 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1E LCE2B LCE2C LCE5A MDFI MEOX2 NBPF19 NOTCH2NLA OTX1 P4HB PLSCR1 PLSCR3 RGS17 RGS19 RGS20 RNF111 SLC39A7 SMCP SPRY1 SPRY2 TGM1 TRIM42 TSPAN4 VASN VWC2 ZNF655	57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF696 ZNF774 ZNF837
Entrez ID		199834	375567
HPRD ID		17264	18271
Ensembl ID		ENSG00000187170	ENSG00000188730
Uniprot IDs		Q5TA78	Q2TAL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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