ELAVL3 and ECSIT

Data Source:
BioGRID (two hybrid)

		ELAVL3	ECSIT
Description		ELAV like RNA binding protein 3	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	MRNA 3'-UTR AU-rich Region Binding	Protein Binding
	Biological Process	Nervous System Development Cell Differentiation	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways			MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27618452) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 27618452)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		9 interacting genes: A2M CDC37 ECSIT ELAVL2 EWSR1 MAST1 NOS3 RNF32 SRPK2	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		1995	51295
HPRD ID		16024	12225
Ensembl ID		ENSG00000196361	ENSG00000130159
Uniprot IDs		Q14576	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?
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