EIF4A1 and PAIP1

Data Source:
HPRD (in vitro, in vivo)

		EIF4A1	PAIP1
Description		eukaryotic translation initiation factor 4A1	poly(A) binding protein interacting protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	RNA Binding Protein Binding Translation Activator Activity
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation MRNA Stabilization
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Deadenylation of mRNA
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	8 interacting genes: EIF3A EIF3B EIF4A1 MYB PABPC1 RND1 UBR5 WWP2
Entrez ID		1973	10605
HPRD ID		04030	05539
Ensembl ID		ENSG00000161960	ENSG00000172239
Uniprot IDs		P60842	Q9H074
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	1JH4 3NTW 3RK6
Enriched GO Terms of Interacting Partners?
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