EIF4A1

Description		eukaryotic translation initiation factor 4A1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Novel Interacting Genes		1 novel interacting genes: MYH10
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2
Entrez ID		1973
HPRD ID		04030
Ensembl ID		ENSG00000161960
Uniprot IDs		P60842
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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