ARID2 and PRICKLE1

Data Source:
BioGRID (pull down, x-ray crystallography)

		ARID2	PRICKLE1
Description		AT-rich interaction domain 2	prickle planar cell polarity protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane	Nucleus Cytosol Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding
	Biological Process	Heart Morphogenesis Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Homeostatic Process Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Asymmetric localization of PCP proteins
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		6 interacting genes: CCNA1 NFYC SMARCA4 SMARCE1 SUMO2 TSC22D2	7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP
Entrez ID		196528	144165
HPRD ID		16505	16341
Ensembl ID		ENSG00000189079	ENSG00000139174
Uniprot IDs		Q68CP9	A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs
Enriched GO Terms of Interacting Partners?
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