PRICKLE1 and UTP14C

Data Source:
BioGRID (two hybrid)

		PRICKLE1	UTP14C
Description		prickle planar cell polarity protein 1	UTP14C small subunit processome component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Nuclear Membrane	Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	RRNA Processing Multicellular Organism Development Spermatogenesis Cell Differentiation Meiotic Cell Cycle
Pathways		Asymmetric localization of PCP proteins	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	31 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA
Entrez ID		144165	9724
HPRD ID		16341	12346
Ensembl ID		ENSG00000139174	ENSG00000253797
Uniprot IDs		A0A024R0W7 B3KVG3 B3KVG6 Q96MT3	A0A024RDV0 Q5TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?
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