PRICKLE1 and VIP

Data Source:
HPRD (in vivo)

		PRICKLE1	VIP
Description		prickle planar cell polarity protein 1	vasoactive intestinal peptide
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Nuclear Membrane	Extracellular Region Neuron Projection Perikaryon
	Molecular Function	Protein Binding Zinc Ion Binding	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Learning Or Memory Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epinephrine Secretion Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Prolactin Secretion
Pathways		Asymmetric localization of PCP proteins	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2
Entrez ID		144165	7432
HPRD ID		16341	15950
Ensembl ID		ENSG00000139174	ENSG00000146469
Uniprot IDs		A0A024R0W7 B3KVG3 B3KVG6 Q96MT3	P01282
PDB IDs			2RRH 2RRI
Enriched GO Terms of Interacting Partners?
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