NFATC2 and IRF2BP2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NFATC2	IRF2BP2
Description		nuclear factor of activated T cells 2	interferon regulatory factor 2 binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Phosphatase Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cytokine Production Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To Drug Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Immature B Cell Differentiation Regulation Of Transcription By RNA Polymerase II
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 28552196) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Monocyte count ( 32888494) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 32499647 30718926) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 22688191) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 32203549 28334899) Life threatening arrhythmia ( 22247754) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Total cholesterol levels ( 28334899) White blood cell count (eosinophil) ( 28158719)
Interacting Genes		18 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ	6 interacting genes: ERBB2 ERBB3 ERBB4 IRF2 MTNR1B NFATC2
Entrez ID		4773	359948
HPRD ID		02730	17160
Ensembl ID		ENSG00000101096	ENSG00000168264
Uniprot IDs		B5B2P4 Q13469	Q7Z5L9
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?
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