EFNA4 and EPHA8

Data Source:
HPRD (in vivo)

		EFNA4	EPHA8
Description		ephrin A4	EPH receptor A8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Cell-cell Signaling Axon Guidance Ephrin Receptor Signaling Pathway	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 MAP2K4 TMEM147 TRARG1	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		1945	2046
HPRD ID		03224	01493
Ensembl ID		ENSG00000243364	ENSG00000070886
Uniprot IDs		P52798	P29322
PDB IDs			1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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