EPHA8 and AK4

Data Source:
BioGRID (two hybrid)

		EPHA8	AK4
Description		EPH receptor A8	adenylate kinase 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus	Liver Development Regulation Of Oxidative Phosphorylation Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Brain Development Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Response To Drug AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Nucleoside Monophosphate Phosphorylation Cellular Response To Hypoxia Regulation Of ATP Biosynthetic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Interconversion of nucleotide di- and triphosphates
Drugs		Fostamatinib
Diseases
GWAS			Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	4 interacting genes: APP CEP19 EPHA8 KEAP1
Entrez ID		2046	205
HPRD ID		01493	00048
Ensembl ID		ENSG00000070886	ENSG00000162433
Uniprot IDs		P29322	F8VS11 P27144
PDB IDs		1UCV 1X5L 3KUL	2AR7 2BBW 3NDP
Enriched GO Terms of Interacting Partners?
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